Figure 1.

15d-PGJ₂ attenuated collagen-induced arthritis. PPAR-γ mRNA expression was quantified by real-time PCR in draining lymph nodes from naïve (white bar) or collagen-immunized and challenged DBA/1 (black bar) mice on the seventh day of disease (a). Arthritic mice were treated by the subcutaneous route with vehicle (○) or 15d-PGJ₂ (1 mg/Kg) (●) for 7 d. Mice were monitored for disease progression as indicated by clinical scores (b), number of affected paws (c), hypernociception (d), and edema (e). Results are presented as the mean ± SEM, N = 8–10; ^∗ P < 0.05 compared with the PBS-treated group.