Figure 3.

Decreased inflammatory cytokines in articular joints from 15d-PGJ₂-treated arthritic mice. Ankle joints from naïve (Δ) or PBS- (○) or 15d-PGJ₂-treated (●) arthritic mice were collected after 7 days of treatment for the determination of TNF-α (b), IFN-γ (d), IL-17 (c), and IL-12 (a) levels by ELISA in the homogenate supernatants. Results are expressed as the mean ± SEM, N = 4 (naïve) and 9-10 (arthritic groups). ^# P < 0.05 compared with naïve group. ^∗ P < 0.05 compared with arthritic mice treated with PBS (vehicle).