Table 2.
Univariate and multivariate logistic analyses to predict high BNP.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | |
| Age (years) | 1.12 | 1.10–1.14 | <0.0001 | 1.08 | 1.05–1.10 | <0.0001 |
| Men/women | 0.71 | 0.51–0.98 | 0.0382 | 0.76 | 0.54–1.08 | 0.1300 |
| BMI | 0.97 | 0.92–1.02 | 0.2485 | |||
| Previous CVD | 5.94 | 4.22–8.36 | <0.0001 | 3.53 | 2.46–5.07 | <0.0001 |
| Previous cancer | 1.31 | 0.47–3.64 | 0.6049 | |||
| Previous liver disease | 0.56 | 0.14–2.31 | 0.4259 | |||
| Smoking | 1.32 | 0.94–1.85 | 0.1116 | |||
| Alcohol consumption | 1.09 | 0.77–1.52 | 0.6289 | |||
| Hypertension | 2.27 | 1.63–3.12 | <0.0001 | 1.18 | 0.82–1.70 | 0.3697 |
| Diabetes mellitus | 1.82 | 1.08–3.08 | 0.0245 | 1.55 | 0.88–2.72 | 0.1258 |
| Systolic BP | 1.02 | 1.01–1.03 | 0.0016 | |||
| Diastolic BP | 1.00 | 0.99–1.02 | 0.6309 | |||
| HbA1c∗ | 1.10 | 0.96–1.27 | 0.1785 | |||
| FBS∗ | 1.03 | 0.84–1.18 | 0.6466 | |||
| eGFR∗ | 0.47 | 0.37–0.57 | <0.0001 | 0.71 | 0.58–0.86 | 0.0007 |
| AST∗ | 1.04 | 0.97–1.12 | 0.2523 | |||
| ALT∗ | 0.79 | 0.65–0.97 | 0.0234 | |||
| γ-GTP∗ | 1.04 | 0.66–1.18 | 0.3552 | |||
| AST/ALT ratio∗ | 1.59 | 1.39–1.81 | <0.0001 | 1.31 | 1.13–1.53 | 0.0004 |
ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; BNP, brain natriuretic peptide; BP, blood pressure; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; FBS, fasting blood sugar; γ-GTP, gamma glutamyl transpeptidase; HbA1c, glycosylated hemoglobin A1c; OR, odds ratio.
∗Per 1-SD increase.