Table 5.
Clinical characteristics between subjects with high and low AST/ALT ratio.
| Variables | Low AST/ALT ratio | High AST/ALT ratio | P value |
|---|---|---|---|
| n = 3157 | n = 337 | ||
| Age (years) | 62 ± 10 | 68 ± 11 | <0.0001 |
| Men/women | 160/177 | 1402/1755 | 0.2815 |
| BMI, kg/cm2 | 23.7 ± 3.1 | 22.1 ± 3.1 | <0.0001 |
| Previous CVD, n (%) | 380 (12%) | 79 (22%) | <0.0001 |
| Previous cancer, n (%) | 62 (2%) | 12 (3%) | 0.0869 |
| Previous liver disease, n (%) | 73 (2%) | 9 (3%) | 0.8255 |
| Smoking, n (%) | 998 (32%) | 123 (34%) | 0.3306 |
| Alcohol consumption, n (%) | 1291 (41%) | 163 (46%) | 0.1125 |
| Hypertension, n (%) | 1134 (36%) | 144 (40%) | 0.1305 |
| Diabetes mellitus, n (%) | 229 (7%) | 12 (3%) | 0.0052 |
| Systolic BP, mmHg | 134 ± 16 | 135 ± 17 | 0.4902 |
| Diastolic BP, mmHg | 80 ± 10 | 78 ± 10 | 0.0050 |
| HbA1c, % | 5.7 ± 0.7 | 5.5 ± 0.5 | <0.0001 |
| FBS, mg/dL | 95 ± 17 | 92 ± 12 | 0.0004 |
| eGFR, mL/min/1.73 m2 | 82 ± 16 | 77 ± 16 | <0.0001 |
| Log H-FABP, ng/mL | 1.23 ± 0.43 | 1.34 ± 0.45 | <0.0001 |
| Log BNP, pg/mL | 2.95 ± 0.84 | 3.42 ± 0.90 | <0.0001 |
| AST, IU/L | 24.8 ± 9.7 | 27.4 ± 25 | 0.0002 |
| ALT, IU/L | 24.3 ± 13.8 | 15.0 ± 13.2 | <0.0001 |
| γ-GTP, IU/L | 36 ± 45 | 34 ± 66 | 0.3455 |
Data are expressed as mean ± standard deviation or number (%).
ALT, alanine transaminase; AST, aspartate transaminase; BMI, body mass index; BNP, brain natriuretic peptide; BP, blood pressure; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; FBS, fasting blood sugar; γ-GTP, gamma glutamyl transpeptidase; HbA1c, glycosylated hemoglobin A1c; H-FABP, heart type fatty acid binding protein.