Table 8. In vivo Oral Activity in the P. berghei Mouse Model Peter’s Test.
4 × 30 mg/kg |
4 × 10 mg/kg |
4 × 3 mg/kg |
4 × 1 mg/kg |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
compd | activity (%) | survival (days) | cure | activity (%) | survival (days) | cure | activity (%) | survival (days) | cure | activity (%) | survival (days) | cure |
25 | 93.0 | 7 | ||||||||||
27 | 99.8 | 22 | 1/3 | 99.7 | 15 | 96.0 | 9 | 48.0 | 6.0 | |||
30 | 99.9 | 10 | 99.9 | 8 | 98.0 | 6 | 90.0 | 7 | ||||
2 | 99.9 | >30 | 3/3 | 99.9 | >30 | 3/3 | 99.9 | 25 | 2/3 | 99.9 | 14 | |
40 | 99.8 | 11.0 | ||||||||||
41 | 99.9 | 14 | ||||||||||
43 | 99.0 | 7 | ||||||||||
44 | <40 | |||||||||||
49 | 99.1 | 20.3 | 1/3 | 99.2 | 9.3 |