Skip to main content

View full-text article in PMC

. 2016 Sep 10;59(21):9672–9685. doi: 10.1021/acs.jmedchem.6b00723

Table 9. In vivo Pharmacokinetic Parameters in Male Sprague Dawley Rat.

	intravenous at 1 mg/kg			oral at 3 mg/kg
compd	Clb (mL min^–1 kg^–1)	Vd_ss (L/kg)	T_1/2 (h)	C_max (ng/mL)	T_max (h)	AUC (ng·min/mL)	F (%)
2^a	18	15	10	180^b	4^b	200542^b	84
41	32	10	4	29	8	30400	33

^a

Data for this compound reported previously.⁵

^b

po dose: 5 mg/kg.