Scheme 3. Synthesis of Payloads 4 and LP3.
Reagents and conditions: (a) Pd/C, H2; (b) HATU, N-Fmoc glycine, DIPEA, rt; (c) TFA, reflux; (d) 9, DIPEA, rt; (e) diethylamine, rt; (f) 6, DIPEA, rt.
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