. 2016 Jun 22;7(11):977–982. doi: 10.1021/acsmedchemlett.6b00195

Table 1. In Vitro Cytotoxicity of Representative Payloads^a.

compd	R	N87 IC₅₀ (nM)	BT474 IC₅₀ (nM)	MDA-MB-453 IC₅₀ (nM)	HT29 IC₅₀ (nM)
2	OAc	1.1	1.0	0.79	0.76
3	OH	>100	>100	>100	>100
4	OC(O)NHEt	1.9	0.99	1.6	1.5

Reported IC₅₀ is the mean of 2–13 independent determinations.

Table 1. In Vitro Cytotoxicity of Representative Payloadsa.