Table 2.

ADA, cell proliferation and cytokine production after drug interruption

ADA+ patients	Months after interruption	ADA (OD)	Mitogenic index	IFN‐γ	IL‐13	IL‐10
1	14	2.111	4.64	+	+	–
2	12	2.752	19	+	–	–
3	16	2.438	8.07	–	–	+
4	17	0.806	0.35	–	–	–
5	69	1.313	13.6	–	+	–
6	99	2.160	0.68	+	–	+
7	88	2.110	19.9	–	+	–
8	96	0.281	11.97	+	+	+

ADA– patients	Months after interruption	ADA (OD)	Mitogenic index	IFN–γ	IL–13	IL–10
1	16	0.063	1.4	–	–	–
2	12	0.041	0.03	+	+	–
3	8	0.089	0.27	–	–	–
4	5	0.039	1.52	–	–	–
5	48	0.016	0.02	–	–	–
6	84	0.065	0.82	–	–	–
7	85	0.045	1.02	–	–	–
8	49	0.039	0.28	–	–	–

ADA = anti‐drug antibodies; OD = optical density; IFN = interferon; IL = interleukin.