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. 2016 Oct 4;186(3):292–303. doi: 10.1111/cei.12857

Figure 2.

Figure 2

Development of collagen type II‐induced arthritis (CIA) in apolipoprotein E (ApoE) mutant mice; 8–12‐week‐old B10.RIII.wild‐type (WT), B10.RIII.ApoE +/– and B10.RIII.ApoE –/– mice were immunized with collagen type II‐complete Freund's adjuvant (col II‐CFA). (a) Clinical severity of CIA in individual mice 8 weeks after immunization with col II. Bars represent the mean values. (b) Representative radiological images of the front paws from B10.RIII.WT, B10.RIII.ApoE +/– and B10.RIII.ApoE –/– mice before and 8 weeks after immunization with col II. (c) Severity score of individual radiological signs, expressed as the mean ± standard deviation (seven to 10 mice/group), 8 weeks after immunization. Bars represent the mean values. Results from (a) to (c) are representative of four independent experiments. Statistical differences are indicated as follows: n.s. = non‐significant; *P < 0·05; **P < 0·01; ***P < 0·005.