Fig. 2.

Schematic model of the role of miRNA in UHRF1 regulation in cancer cells. Several miRNAs act as tumor-suppressor by binding to the 3′-untranslated region (3′-UTR) of mRNA UHRF1 leading to its degradation. TQ increases the expression of miR-34a which leads to upregulation of p53 in wild type p53 cancer cells or p73 in p53-mutated cancer cells with subsequent UHRF1 inhibition. UHRF1 downregulation results in the reactivation of others TSGs including p16 ^INK4A, BRCA1, PPARG and KiSS1 conducting to cell proliferation inhibition and apoptosis