Table 6.
| Drug Class and Drug | Usual Dosage | Route of Excretion | Removal with Dialysis, % | Supplement Dose for Dialysis, mg |
| Angiotensin–converting enzyme inhibitors | ||||
| Benazepril | 5–40 mg every day | K (L) | 20–50 | 5–10 |
| Captopril | 12.5–50 mg three times per day | K | 50 | 12.5–25 |
| Enalapril | 2.5–10 mg every 12 h | K (L) | 50 | 2.5–5 |
| Fosinopril | 10 mg every day | K (L) | None | None |
| Lisinopril | 2.5–10 mg every daya | K | 50 | 2.5–5 |
| Perindopril | 2–8 mg every day | K (L) | 50 | 2 |
| Ramipril | 5–10 mg every day | K (L) | 20 | 2.5 |
| Trandolapril | 0.5–4 mg every day | K (L) | 30 | 0.5 |
| Angiotensin receptor blockers | ||||
| Candesartan | 8–32 mg/d | K (L) | None | None |
| Eprosartan | 600–1200 mg/d | L | None | None |
| Irbesartan | 75–300 mg/d | L | None | None |
| Losartan | 50–100 mg every day | K (L) | None | None |
| Olmesartan | 10–40 mg/d | K (L) | None | None |
| Telmisartan | 40–80 mg/d | L | None | None |
| Valsartan | 80–320 mg every day | K (L) | None | None |
| Mineralocorticoid receptor antagonists | ||||
| Spironolactone | 25–50 mg every day | K (L) | None | None |
| Eplerenone | 50–100 mg every day | K (L) | None | None |
| β-Blockers | ||||
| Atenolol | 25 mg every dayb | K (L) | 50 | 25–50 |
| Bisoprostol | 2.5–20 mg every day | L | None | None |
| Carvedilol | 25 mg twice a day | L (K) | None | None |
| Labetalol | 200–600 mg twice a day | K (L) | None | None |
| Metoprolol | 50–100 mg twice a day | K (L) | None | None |
| Nadolol | 80–100 mg twice a day | K | 50 | 80 |
| Propranolol | 80–160 mg twice a day | K | None | None |
| Calcium-channel blockers | ||||
| Amlodipine | 2.5–10 mg every day | L | None | None |
| Felodipine | 5–10 mg every day | L | None | None |
| Nicardipine | 20–40 mg three times a day | L | None | None |
| Nifedipine XL | 30–90 mg every day | L | None | None |
| Lacidipine | 2–6 mg/d | L (K) | None | None |
| Manidipine | 10–20 mg/d | L | None | None |
| Diltiazem CD | 180–360 mg | L (K) | None | None |
| Verapamil CD | 180–360 mg every day | L (K) | None | None |
| α-Adrenergic blockers | ||||
| Doxazosin | 1–16 mg every day | L | None | None |
| Prazosin | 1–15 mg twice a day | L | None | None |
| Terazosin | 1–20 mg every day | L | None | None |
| Others | ||||
| Clonidine | 0.1–0.3 mg twice a day/three times a day | K (L) | 5 | None |
| Hydralazine | 25–50 mg three times a day/twice a day | L | 25–40 | None |
K, kidney; L, liver.
a
Preferred dosage for lisinopril is 10–40 mg three times weekly after dialysis. The maximum dose recommended in hemodialysis patients is 40 mg per day.
b
Preferred dosage for atenolol is 25 mg–100 mg three times weekly after dialysis to maximize the antihypertensive effect and convenience of dosing.