Table 4.

Major bleeding risk in atrial fibrillation patients with ESRD treated with warfarin

Study	Country	Design	N	Adjusted HR Major Bleeding (95% CI)
Shen et al., 2015 (2)	United States	Retrospective	12,284 (1838 warfarin users)	GI bleeding: 1.36 (0.89 to 2.07)
				Hemorrhagic stroke: 1.92 (0.82 to 4.48)
Shah et al., 2014 (3)	Canada	Retrospective	1626 (756 warfarin users)	1.44 (1.13 to 1.85)
Genovesi et al., 2014 (4)	Italy	Prospective	290 (134 on warfarin)	3.96 (1.15 to 13.68)
Olesen et al., 2012 (5)	Denmark	Retrospective	901 (178 on warfarin)	2.70 (2.38 to 3.07)
Winkelmayer et al., 2011 (6)	United States	Retrospective	2313 (warfarin in 249)	GI bleeding: 0.90 (0.60 to 1.35)
				Hemorrhagic stroke: 2.63 (1.01 to 6.88)

HR, hazard ratio; 95% CI, 95 % confidence interval; GI, gastrointestinal.