Figure 2.

Hazard ratios (HRs) for subgroups of patients with CKD stage 3 from two randomized trials comparing anticoagulation with aspirin. For warfarin comparison from the SPAF III Study, the outcome was ischemic stroke and systemic embolism, and the aspirin group additionally received low ineffective doses of warfarin. For apixaban, the outcome was stroke and systemic embolism. 95% CI, 95% confidence interval; INR, international normalized ratio SPAF III, Stroke Prevention in Atrial Fibrillation. Reprinted from reference 6, with permission.