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. 2016 Nov 14;7:493. doi: 10.3389/fimmu.2016.00493

Figure 5.

Figure 5

Increase in blood group IgG anti-A/B antibodies in healthy individuals and in patients with type I DM after immunization with Pn23 vaccine as determined with the Biacore® device. To determine IgM (A) and IgG (B) anti-A/B antibodies in healthy individuals and patients with type I DM prior and post immunization with Pneumo 23 Vaccine “Pasteur Merieux” (Pn23), an anti-human IgM mAb (A) or anti-human IgG Abs (B) were applied as the second step reagents as described in Section “Materials and Methods.” Results are depicted using box plot diagrams, with the median represented by a cross, the interquartile range (IQR) represented by the box, and 5- and 95-percentile values represented by the whiskers; statistically significant differences between study groups were calculated using the non-parametric two-tailed Mann–Whitney U-test. For the IgM antibody response, no statistically significant differences were found between study groups.