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. 2016 Aug 18;7(8):e2340. doi: 10.1038/cddis.2016.242

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a and b) Infection with VACV or MCMV protects Mcl-1-deficient MEF cells against ABT-737. MEF Mcl-1^−/− cells and MEF Mcl-1^−/− reconstituted with mMcl-1 were infected with VACV (a) or MCMV (b) (MOI=10) for 16 h. Then, 1 μM ABT-737 was added for additional 4 h where indicated. Apoptosis induction was measured as the percentage of cells positive for active caspase-3 by flow cytometry. Data show means/S.E.M. of three independent experiments (**P=0.0013 (a); **P=0.0016 (b); two-tailed paired t-test)