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. 2016 Aug 18;7(8):e2340. doi: 10.1038/cddis.2016.242

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Infection with MVA induces cell death in macrophages independent of Mcl-1 deficiency (a and b), but is enhanced when Bcl-X_L is absent (c and d). On day 7 of differentiation, macrophages wt, Mcl-1^−/− (a and b) or wt, Bcl-X_L^−/− (c and d) were infected with MVA (MOI=10) for 16 h. Cell death was measured as the percentage of cells positive for PI (a and c) and apoptosis induction as the percentage of cells positive for active caspase-3 (b and d) by flow cytometry. Data show means/S.E.M. of three (a), five (b) or six (c and d) independent experiments (ns, P=0.88 (a); ns, P=0.24 (b); ***P=0.0002 (c); ns, P=0.12 (d); ns, not significant; two-tailed unpaired t-test)