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. 2016 Aug 18;7(8):e2340. doi: 10.1038/cddis.2016.242

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The amount of released infectious viral particles is reduced in Bcl-X_L^−/− macrophages compared with wt during VACV infection. On day 7 of differentiation, wt or Bcl-X_L^−/− macrophages were infected with VACV (MOI=10) for 16 h. Plaque assay was performed to measure infectious virus particles using infected cells plus supernatant at 1 : 1000 dilution. The number of plaques was counted. Number of plaques from wt cells was set to 100%. Data show means/S.E.M. of eight independent experiments with duplicate samples each (***P=0.00005; two-tailed unpaired t-test). (b) Treatment with ABT-737 reduced the amount of released infectious viral particles during VACV infection in macrophages. On day 7 of differentiation, wt macrophages were infected with VACV (MOI=10) for 16 h. Then, 1 μM ABT-737 was added for additional 4 h where indicated. Plaque assay was performed to measure infectious virus particles using infected cells plus supernatant at 1 : 1000 dilution. The number of plaques was counted. Number of plaques from untreated cells was set to 100%. Data show means/S.E.M. of five independent experiments with duplicate samples each (***P=0.0006; two-tailed paired t-test)