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. 2016 Aug 25;7(8):e2346. doi: 10.1038/cddis.2016.245

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The NEMO-A323P interferes with the TNF-induced Caspases activation process in an IKK-independent manner. (a) KO, NEMO and NEMO-A323P cells were treated with 10 ng/ml TNF for the indicated times (min: minutes). Cells were lysed and subjected to immunoblot analysis for the indicated proteins. One representative of two independent experiments is shown. (b and c) KO, NEMO and NEMO-A323P cells were treated with TNF for the specified time periods (h: hours) to study the effect of TNF-induced Caspases activation. Time course of Caspase-8 and Caspase-3/7 proteolytic activity was calculated. In (d), the same cells were treated for 6 h with TNF alone or with TPCA-1. Caspase-3/7 proteolytic activity was calculated. Data are presented as mean±S.E.M. (three independent experiments performed). *P-value<0.01 (Student's t-test)