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. 2016 Jun 30;7(6):e2284. doi: 10.1038/cddis.2016.187

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Cycloheximide (CHX) chase experiments in transfected Hep3B cells in normoxia. (a) Western blot analysis of HIF-1α and ARNT degradation after CHX treatment (100 μM) in control (ctrl.) and pHIF-1α-transfected cells. Protein masses are given in kDa. Representative result of n=3 independent experiments. (b) Quantitation of ARNT degradation. Values represent mean±S.E.M. of n=3 (except ctrl. 1 h: n=2) independent experiments; lin. reg.: linear regression. (c) Quantitation of HIF-1α degradation in pHIF-1α-transfected cells. Values represent mean±S.E.M. of n=3 independent experiments