Figure 1.

Pedigree of the affected family with hepatocellular carcinoma showing FAH variant status. Whole exome sequencing was done on three family members (denoted with *): the proband (black arrow), unaffected sibling, and mother. Both parents were carriers for the p.R142G variant in the FAH gene. Two other children in this family were sequenced and found to be heterozygous carriers for this variant. The three children with liver disease had the p.R142G homozygous variation in FAH. Gray shading indicates that variant status was not determined.