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. 2016 Aug 29;36(6):1127–1173. doi: 10.1002/med.21401

Figure 2.

Figure 2

Chemical structures of the minimal cap analogue m7GTP and reported inhibitors of cap‐binding and X‐ray structures of the PB2‐CBD in complex with the corresponding ligands. (A–D) Comparison of the crystal structures of the PB2‐CBD of influenza A32 (A; PDB: 2VQZ) or influenza B33 (B; PDB: 5EFA) PB2‐CBD in complex with m7GTP; and influenza A PB2‐CBD with bound compound “11”36 (C; PDB: 4CB6) or VX‐78737 (D; PDB: 4P1U). (E) Cap‐binding inhibitors Cap‐3 and Cap‐7.38 (F) For RO0794238,39 direct binding to the PB2‐CBD could not be demonstrated.