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. 2016 Jul 20;40(9):1846–1856. doi: 10.1111/acer.13148

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Copyright © 2016 The Authors Alcoholism: Clinical and Experimental Research published by Wiley Periodicals, Inc. on behalf of Research Society on Alcoholism

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Nuclear overexpression of Trx1 mitigates the exaggerated TGF β1 expression induced by chronic alcohol ingestion following bleomycin‐induced lung injury in NLS‐Tg mice as compared to littermates. 3‐month‐old WT or NLS‐Tg were treated ± alcohol (20% v/v in water for 8 weeks) then treated with 2 units/kg bleomycin intratracheally. Lungs and BAL fluid were harvested at 14 days after and analyzed for activated TGF β1 in BALF by ELISA. *p < 0.05 increased compared to untreated WT. **p < 0.05 increased compared to control‐fed, bleomycin‐treated WT. ^# p < 0.05 decreased compared to alcohol‐fed, bleomycin‐treated WT. N = 4 to 6.