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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Cytokine. 2016 Jun 20;87:9–19. doi: 10.1016/j.cyto.2016.06.010

Figure 2. IL-4 regulation in Tfh cells.

Figure 2

i) IL-4/STAT6 signalling leads to upregulation of Batf that in turn cooperates with IRF4 to bind to CNS2 region promoting IL-4 production. ii) Batf is also upregulated by IL-6/STAT3 signalling further activating c-MAF which binds to CNS locus leading to IL-4 production.