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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Immunol Rev. 2016 Nov;274(1):9–15. doi: 10.1111/imr.12474

Figure 6. Functions of C3(H2O) by location.

Figure 6

Intracellular C3(H2O) is a source of C3a that could then engage the C3aR, it is secreted and C3 fragments are generated by cofactor activity, some of which contain C3a. Extracellular C3(H2O) is regulated by cofactor activity, taken up into cells and initiates the AP.