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HIV-1 protein effects on novelty-seeking behaviors in HIV-1Tg rats (N = 14) and F344 control rats (N = 23). (A) Number of head dips measured during the 10-min session in the hole-board test; (B) Number of center entries. (C) Center time measured during the 10-min session in the open field test. HIV-1Tg rats demonstrated significantly greater baseline novelty-seeking behaviors in each of these paradigms.
