Table 3.
A list of addiction-related genes whose expression levels differed significantly in the NAc between the F344 Saline and HIV-1Tg Saline (n= 6–8 per group).
| Gene Name | Gene Function | F344 _Saline (FS) | HIV-1Tg _Saline (HS) | Ratio (HS/FS) | P-Value |
|---|---|---|---|---|---|
| Drd1 | Dopamine receptor D1 | 4.72E-02 ± 6.43E-03 | 9.86E-02 ± 1.74E-02 | 2.09 | 0.032 |
| Htr1a | 5-Hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | 1.72E-03 ± 1.26E-04 | 6.46E-03 ± 9.05E-04 | 3.76 | 0.0006 |
| Htr1b | 5-Hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 2.99E-02 ± 2.99E-03 | 1.92E-02 ± 2.44E-03 | 0.64 | 0.032 |
| Htr7 | 5-Hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | 2.29E-03 ± 1.71E-04 | 6.20E-03 ± 9.56E-04 | 2.71 | 0.0027 |
| Slc6a4 | 5-Hydroxytryptamine (serotonin) transporter | 8.75E-05 ± 1.16E-05 | 1.64E-04 ± 2.45E-05 | 1.87 | 0.030 |
| Gabra1 | Gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 7.79E-02 ± 6.15E-03 | 1.50E-01 ± 2.57E-02 | 1.92 | 0.013 |
| Chrna2 | Cholinergic receptor, nicotinic, alpha 2 (neuronal) | 6.21E-05 ± 1.49E-05 | 1.71E-04 ± 2.92E-05 | 2.75 | 0.009 |
| Chrna3 | Cholinergic receptor, nicotinic, alpha 3 (neuronal) | 7.30E-04 ± 6.83E-05 | 1.17E-03 ± 8.45E-05 | 1.60 | 0.006 |
| Chrna4 | Cholinergic receptor, nicotinic, alpha 4 (neuronal) | 1.35E-03 ± 1.92E-04 | 2.34E-03 ± 3.35E-04 | 1.73 | 0.034 |
| Chrnb2 | Cholinergic receptor, nicotinic, beta 2 (neuronal) | 4.08E-02 ± 3.00E-03 | 5.85E-02 ± 7.31E-03 | 1.44 | 0.033 |
| Chrnb4 | Cholinergic receptor, nicotinic, beta 4 (neuronal) | 5.47E-04 ± 7.04E-05 | 8.29E-04 ± 7.55E-05 | 1.52 | 0.032 |
| Gria1 | Glutamate receptor, ionotropic, AMPA 1 | 1.40E-01 ± 9.19E-03 | 1.96E-01 ± 7.53E-03 | 1.40 | 0.006 |
| Grm1 | Glutamate receptor, metabotropic 1 | 1.56E-02 ± 1.14E-03 | 2.40E-02 ± 9.79E-04 | 1.54 | 0.001 |
| Grin1 | Glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 1.08E-01 ± 1.00E-02 | 1.82E-01 ± 1.76E-02 | 1.69 | 0.007 |
| Grin2c | Glutamate receptor, ionotropic, N-methyl D-aspartate 2C | 1.58E-02 ± 1.55E-03 | 2.49E-02 ± 3.05E-03 | 1.57 | 0.045 |
| Grin2d | Glutamate receptor, ionotropic, N-methyl D-aspartate 2D | 5.95E-03 ± 4.94E-04 | 2.27E-02 ± 9.45E-04 | 3.82 | <0.0001 |
| Il1r1 | Interleukin 1 receptor, type I | 1.53E-03 ± 1.70E-04 | 6.06E-04 ± 1.69E-04 | 0.40 | 0.004 |
| Il1r2 | Interleukin 1 receptor, type II | 4.89E-04 ± 6.88E-05 | 2.37E-04 ± 4.23E-05 | 0.48 | 0.021 |
| Il1a | Interleukin-1 alpha | 2.24E-04 ± 1.37E-05 | 1.50E-04 ± 1.88E-05 | 0.67 | 0.019 |
| Il6r | Interleukin 6 receptor | 3.05E-03 ± 7.88E-05 | 4.83E-03 ± 5.55E-04 | 1.58 | 0.034 |
| Il12a | Interleukin 12A | 3.05E-03 ± 2.45E-04 | 4.91E-03 ± 6.37E-04 | 1.61 | 0.021 |