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. 2016 Nov 10;11:5917–5930. doi: 10.2147/IJN.S113658

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© 2016 Li et al. This work is published and licensed by Dove Medical Press Limited

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Drug loading and release of sulfated PBNPs with IFN-FITC as the model protein therapeutics.

Notes: (A) Adsorption of IFN-FITC by PBNP (white), PBNP-S5 (gray) and PBNP-S10 (black) at different pH values. (B) Release of IFN-FITC from PBNP (circle), PBNP-S5 (inverted triangle) and PBNP-S10 (triangle) in VFS with (blue) or without mucin (gray). Mean ± SD, n=3. *P<0.05 and **P<0.01.

Abbreviations: PBNPs, phenylboronic acid-rich nanoparticles; IFN-FITC, fluorescein isothiocyanate-labeled interferon; PBNP-S, sulfonate-modified phenylboronic acid-rich nanoparticles; PBNP-S5, PBNP-S at a weight ratio of 5%; PBNP-S10, PBNP-S at a weight ratio of 10%; VFS, vaginal fluid simulant; SD, standard deviation.