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. 2016 Nov 8;9:6909–6914. doi: 10.2147/OTT.S117338

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© 2016 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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miR-486-5p directly targets SNAI1.

Notes: (A) TargetScan program predicts that SNAI1 is a direct target of miR-486-5p. The seed sequence of miR-486-5p in the 3′-UTR of SNAI1 is indicated in red. (B) Western blot results show the increased expression of Snail protein in metastatic C4-2 cells compared to the non-metastatic LNCaP, which is reversely correlated with miR-486-5p expression. (C) Western blot results show a decreased expression of Snail and N-cadherin and an increased expression of E-cadherin in the C4-2 cells transfected with miR-486-5p mimics compared to those transfected with scramble sequence. (D) The luciferase activity is significantly decreased in C4-2 cells transfected with miR-486-5p mimics (**P<0.01).

Abbreviation: UTR, untranslated region.