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. 2016 Nov 10;11:5959–5969. doi: 10.2147/IJN.S116867

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© 2016 Wen et al. This work is published and licensed by Dove Medical Press Limited

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Cochlear entry of different surface-modified DiR-loaded NPs 24 h after intratympanic administration.

Notes: (A) Fluorescence images of excised cochleae 24 h after intratympanic administration of various surface-modified DiR-loaded NPs. (B) Fluorescence quantification of the total amount of fluorescence in the excised cochleae (*P<0.05, **P<0.01, ***P<0.001). Results are shown as mean ± SD (n=3).

Abbreviations: CS, chitosan; DiR, 1,1′-dioctadecyl-3,3,3′,3-tetramethylindotricarbocyanine iodide; mPEG, methoxy poly(ethylene glycol); NPs, nanoparticles; P407, poloxamer 407; PLGA, poly(lactic/glycolic acid); SD, standard deviation; h, hours.