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. 2016 Nov 10;11:5959–5969. doi: 10.2147/IJN.S116867

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© 2016 Wen et al. This work is published and licensed by Dove Medical Press Limited

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Localization of different surface-modified, coumarin-6-loaded NPs in OHCs 24 h after intratympanic application.

Notes: Scales in the figure represent 10 µm. (A) Control, NS. (B) PLGA NPs. (C) P407-PLGA NPs. (D) CS-PLGA NPs. (E) mPEG-PLGA NPs. (F) Fluorescence quantification of OHCs (***P<0.001). F-value is the ratio of MFI in each OHC of various PLGA NPs to that of unmodified PLGA NPs. Results are shown as mean ± SD (n=10).

Abbreviations: CS, chitosan; MFI, mean fluorescence intensity; mPEG, methoxy poly(ethylene glycol); NS, normal saline; NPs, nanoparticles; OHCs, outer hair cells; P407, poloxamer 407; PLGA, poly(lactic/glycolic acid); SD, standard deviation; h, hours.