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. 2016 Aug 18;157(12):2709–2721. doi: 10.1097/j.pain.0000000000000690

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© 2016 International Association for the Study of Pain

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Figure 4. — Ang-(1-7) administration in established cancer-induced bone pain does not change nesting behaviors. Nesting, an innate behavior of mice, was studied. During the first hour of the study, the 66.1-inoculated animals, on postsurgery day 6, cleared significantly (P < 0.05) fewer zones than did naive animals (A). After the second hour of the study, the media animals cleared fewer zones than did both the naive and 66.1-inoculated animals (P < 0.05). A second study was conducted in which 66.1-inoculated animals, on postsurgery day 15, were treated with Ang-(1-7) (0.058 μg/kg, i.p.) or vehicle (0.9% saline) (B). The nesting behaviors of both cancerous groups did not differ significantly from that of the naive group. At both 75- and 90-minute time points, media animals cleared fewer zones than did the other 3 groups (P < 0.05). Values represent mean ± SEM, n = 8 per group.