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. 2016 Aug 18;157(12):2709–2721. doi: 10.1097/j.pain.0000000000000690

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© 2016 International Association for the Study of Pain

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Figure 5. — MasR is expressed in the dorsal root ganglion (DRG) and femur extrudate. (A) Ipsilateral DRG were harvested from naive, sham (media inoculated), or chronically treated 66.1-inoculated mice, homogenized, and probed for MasR expression through Western blotting. MasR is expressed in the DRG; MasR bands were observed at ∼50 and ∼40 kDa (B). Sham surgery (ie, media only) did not alter MasR expression levels in the DRG. 66.1 inoculation increased the expression of MasR in the ipsilateral DRG, although not statistically significant. β-actin serves as the loading control (pools of DRG from n = 3-5 animals). (C) Ipsilateral bone marrow extrudate was harvested from naive, sham (media-inoculated), or cancer-inoculated mice and probed for MasR expression through Western blotting. MasR is expressed in the femur extrudates of mice. MasR bands were observed at ∼50 and ∼40 kDa. (D) Sham surgery (ie, media only) did not alter MasR expression levels at ∼40 or ∼50 kDa in the femur extrudate. 66.1 inoculation significantly increased (P < 0.001) the expression of MasR in the ipsilateral femur extrudate. β-actin serves as the loading control (Pools of femur extrudate from n = 3-5 mice).