A, Basal oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) was measured inleukemic splenocytes isolated from TCL1/p53+/+ mice (n=4) and TCL1/p53−/−mice (n=5). Three measurement cycles in duplicate was taken for each mouse sample. Representative graphs for OCR and ECAR are shown. Dotted lines indicate the time points of injection of 1 μM oligomycin (Oligo), 4 μM FCCP, or 2μM Rotenone (Rot). B, Comparison of the mean basal OCR between TCL1/p53+/+ mice (n=4) and TCL1/p53−/− mice (n=5). C, Comparison of the mean ECAR between TCL1/p53+/+ mice (n=4) and TCL1/p53−/− mice (n=5). D, Cellular ATP levels in the splenocytes from TCL1/p53+/+ and TCL1/p53−/− mice (n=4). E, Comparison between TCL1/p53+/+ mice (n=4) and TCL1/p53−/− mice (n=5) for their relative OCR normalized by mitochondrial mass measured by MitoTracker Green staining.