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. Author manuscript; available in PMC: 2017 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2016 May 14;24(24):6276–6290. doi: 10.1016/j.bmc.2016.05.021

Figure 1.

Figure 1

Structural variety of the hygrolide family. (A) Sites of known structural variability in hygrolide antibiotics are indicated. Variations include stereochemistry, glycosylation, acylation, methylation, oxidation state, and ring-opening, among others. (B) Six main scaffolds of the hygrolide antibiotics. Names under the drawings indicate scaffold name rather than the exact name of the natural product(s). (C) Structure of JBIR-100 with the fumarate moiety containing an electrophilic alkene suitable for nucleophilic addition highlighted with a yellow circle.