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. 2016 Nov 15;7:501. doi: 10.3389/fphys.2016.00501

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Copyright © 2016 Bolea, Pueyo, Orini and Bailón.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simulation data scheme is illustrated. Heartbeat time occurrences are detected from ECG. Based on the IPFM model the ANS modulating signal 𝔐(t) is estimated. Spectral analysis by Welch periodogram is computed on (t) in order to estimate the parameters needed for the simulation, frequency and power of LF and HF components, which are used to construct a new set of modulating signals, ^j(t), through ARMA technique, with M = 50 realizations. Then, IPFM model is used to generate simulated heartbeat occurrences $t_{T n}^{j} (k)$ with different values of T from 0.46 to 1.1 s. Simulated RR series are computed from the $t_{T n}^{j} (k)$ .

Inline graphic — Simulation data scheme is illustrated. Heartbeat time occurrences are detected from ECG. Based on the IPFM model the ANS modulating signal 𝔐(t) is estimated. Spectral analysis by Welch periodogram is computed on (t) in order to estimate the parameters needed for the simulation, frequency and power of LF and HF components, which are used to construct a new set of modulating signals, ^j(t), through ARMA technique, with M = 50 realizations. Then, IPFM model is used to generate simulated heartbeat occurrences $t_{T n}^{j} (k)$ with different values of T from 0.46 to 1.1 s. Simulated RR series are computed from the $t_{T n}^{j} (k)$ .