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. 2016 Nov 15;7:501. doi: 10.3389/fphys.2016.00501

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Copyright © 2016 Bolea, Pueyo, Orini and Bailón.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Non-linear HRV indices computed from simulation study varying mean heart period, distribution of all uncorrected nonlinear HRV indices are shown in (blue) circles, corrected by linear regression in (brown) down triangles, corrected by parabolic regression in (green) up triangles, both former cases only subject-specific correction value of non-linear indices for each RR were shown. Finally, HR-corrected non-linear indices by interpolating RR time series at 2, 4, and 8 Hz in (orange) diamonds. Data corresponds to all simulations derived from Fantasia database. Distributions are represented by median and interquartile range.