Figure 2.

Multi-layer approach to multi-omic data integration. Our approach consists of a three-layered model to compare cells in different conditions: the first layer represents the functional similarity of genes (according to the BP domain of GO) on which mutation data from the COSMIC database are mapped; the second layer represents the conformation of the chromatin in the nucleus (according to Hi-C data analyzed with NuChart) on which epigenetic information of cells are mapped, relying on MeDIP-seq experiments; the third layer represents a protein-protein interaction network (according to the STRING database) on which gene expression data are mapped.