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(A) Spontaneous (Spont.) and double-strand break (DSB)-induced thymidine kinase (TK) mutant frequencies in TSCE5 and BLM-TSCE5 cells. (B) Spontaneous and DSB-induced TK revertant frequencies in TSCER2 and BLM-TSCER2 cells. Cells were transfected with the I-SceI expression vector (pCBASce) to induce DSBs. The data are presented as means and SD for four independent experiments. *, P < 0.05; **, P < 0.01; ND, not detected.
