TABLE 1.
Mutation analysis of nonselected TSCE5 and BLM-TSCE5 mutants after I-SceI expression
| Mutation type | No. (%) of mutantsa |
|
|---|---|---|
| TSCE5 cells (480 clones) | BLM-TSCE5 cells (480 clones) | |
| Small deletion (<60 bp) | 8 (53) | 18 (49) |
| Medium-sized deletion (60 bp–1 kb) | 3 (20) | 3 (8.1) |
| Large deletion (>1 kb) | 0 | 6 (16) |
| Insertion (1 bp) | 0 | 2 (5.4) |
| Rearrangement | 4 (27) | 5 (14) |
| Recombination | 0 | 2 (5.4) |
| Translocation | 0 | 1 (2.7) |
| Total | 15 (3.1) | 37 (7.7) |
a
Except for the last row. The data in the last row are numbers (%) among all clones.