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. 2016 Nov 15;7:520. doi: 10.3389/fphys.2016.00520

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Copyright © 2016 Nguyen, Siu, Dewey, Cui and Gomes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Wild-type Fast Skeletal TnI and TnI R174Q on Ca²⁺-sensitivity of force development in skinned rabbit muscle fibers. After TnT treatment the fibers were reconstituted with TnI·TnC complex. Comparison of rabbit fibers after they were reconstituted with wild-type fsTnI or fsTnI R174Q in the presence of fsTnC. The Ca²⁺ dependence of force was measured in each preparation after reconstituting whole Tn. Each point is the average of 3–5 experiments and represents the mean ±S.D.