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. 2016 Aug 8;594(22):6733–6751. doi: 10.1113/JP272162

Figure 8. The membrane excitability of cortical neurons is markedly reduced during the S‐component of the SWD .

Figure 8

A, firing responses of a S1 cortex neuron to iterative injections of depolarizing current pulses (+0.4 nA) in between seizure activity (Aa, Inter‐ictal) and in conjunction with the ECoG spikes during a SWD (Ab, grey shading). Typical cell responses obtained during the inter‐ictal period (I‐I), the S‐component (S) and the W‐component (W) are shown in Ac. The intracellular stimulation could generate an intrinsic burst of APs (arrow in Aa). Calibrations in Ab apply also to Aa. B, pooled data showing the pre‐pulse V m values (left) and the corresponding number of APs generated by the current pulses (right). * P < 0.05; ** P < 0.01; *** P < 0.001.