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. 2016 Nov 15;6:37200. doi: 10.1038/srep37200

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Copyright © 2016, The Author(s)

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(a) Macroscopic analysis of Spink3^+/−;XX^SPINK1 and Spink3^−/−;XX^SPINK1 mice at 8 weeks. Dashed lines delineate the pancreas. (b) Pancreatic tissue sections from mice of the indicated genotype at 8 weeks were stained with H&E (upper panels) or Azan [for collagen (dark blue); lower panels]. Scale bars, 100 μm. (c) Pancreatic cryosections from mice of the indicated genotype were stained for immune cell markers CD68, F4/80, Ly-6G, or CD11b (brown). Right-column panels show enlarged images of the boxed areas in the corresponding middle-column panels. Scale bars, 50 μm. (d–f) qPCR analysis of gene expression for (d) proinflammatory cytokines and chemokines, (e) ER and (f) oxidative stress markers. (g) Reduced glutathione (GSH) levels in pancreas of mice of the indicated genotype at 8 weeks. Values are means ± SEM (n = 4–6 mice). *P < 0.05; **P < 0.01.