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. 2016 Nov 15;6:37200. doi: 10.1038/srep37200

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Copyright © 2016, The Author(s)

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(a) Pancreatic tissue sections from mice of the indicated genotype at 8 weeks were immunostained for desmin or αSMA (brown). Scale bars, 50 μm. Du, duct. (b,c) Up-regulation of (b) stellate cell markers and (c) proto-oncogene products in pancreas of Spink3^−/−;XX^SPINK1 mice at 8 weeks (immunoblot). (d) Pancreatic tissue sections from mice of the indicated genotype at 8 weeks were immunostained for EGFR (brown). Scale bars, 100 μm. (e) Ki67 staining of pancreatic tissue sections and Ki67 labeling index at 8 weeks. Scale bars, 50 μm. Values are means ± SEM (n = 5 mice). **P < 0.01.