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. 2016 Nov 15;6:36790. doi: 10.1038/srep36790

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Copyright © 2016, The Author(s)

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(A) Ox-LDL stimulation results in increased LOX-1 expression. Relative levels of LOX-1 transcripts were determined by RT-qPCR and are expressed as fold changes compared to transcript levels in mock-treated cells. (B) PIAS3 suppresses ox-LDL-induced LOX-1 expression. LOX-1 transcript levels were detected by RT-qPCR and expressed as fold changes compared to transcript levels in EV-transfected cells. (C) PIAS3 inhibits ox-LDL-induced lipid accumulation in RAW264.7 cells, as determined via Oil Red O staining. The red dots represent lipids accumulated in the cells (bar, 10 μm). *P < 0.05.