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. 2016 Nov 15;6:36935. doi: 10.1038/srep36935

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The red (circular) nodes denote the known pharmacokinetics genes of 5-FU. The green (diamond-shaped) nodes denote the cancer-unrelated pCRT-response genes. The yellow (oval) nodes denote the genes overlapped between the cancer-unrelated pCRT-response genes and the known pharmacokinetics genes of 5-FU. ATIC, detected as a cancer-unrelated pCRT-response gene, has the largest number of interaction links with the known pharmacokinetics genes of 5-FU.