Table 2. Enrichment and pathway analysis.

Category		Total	Hits	P-value
Disease-associated
	critical illness (cardiogenic shock)	6	3	0.0016
	Lesch-Nyhan syndrome	5	2	0.0189
	metabolites affected by exercise	5	2	0.0189
	early markers of myocardial injury	14	3	0.0227
	Crigler-Najjar syndrome | glucose-6-phosphate dehydrogenase deficiency | intoxication acetaminophen [dd] | pyruvate kinase deficiency	1	1	0.0464
Enzyme-associated
	GMP reductase	6	3	0.0101
	guanine phosphoribosyltransferase	6	3	0.0101
	carnitine O-palmitoyltransferase	3	2	0.0212
	Beta oxidation of fatty acid	3	2	0.0212
	transport into the mitochondria (carnitine)	4	2	0.0400
	methenyltetrahydrofolate cyclohydrolase	4	2	0.0400
	carnitine transferase	4	2	0.0400
SNP-associated
	rs10827283 | rs9663087	5	2	0.0385
	rs1562861	5	2	0.0385
	rs2039334	5	2	0.0385
Location-associated
	skeletal muscle	45	4	0.0433
Pathway
	Fatty acid biosynthesis	49	3	0.0052
	Purine metabolism	92	3	0.0290