Table 2.

Scoring criteria for the evaluation of histopathological changes in liver architecture and in spleen architecture.

Changes in liver architecture
Ballooning degeneration
Score 0	No ballooning degeneration
Score 1+	Minimal enlargement in few hepatocytes
Score 2+	Mild enlargement in many hepatocytes
Score 3+	Moderate enlargement in most hepatocytes
Score 4+	Severe enlargement in most hepatocytes
Inflammation
Score 0	No inflammatory foci
Score 1+	1 inflammatory foci per 200 hpf
Score 2+	2–4 inflammatory foci per 200 hpf
Score 3+	>4 inflammatory foci per 200 hpf
Apoptotic cells
Score 0	No apoptotic cells
Score 1+	Few apoptotic cells
Fibrosis
Score 0	No fibrosis
Score 1+	Portal/sinusoidal minimal fibrosis
Score 2+	Portal/sinusoidal mild fibrosis
Score 3+	Bridging fibrosis
Score 4+	Cirrhosis
Changes in spleen architecture
Lymphoid necrosis
Score 0	No necrotic foci
Score 1+	<5% necrotic foci per 200 hpf (mini)
Score 2+	5–25 necrotic foci per 200 hpf (mild)
Score 3+	25–50 necrotic foci per 200 hpf (moderate)
Score 4+	>50% necrotic foci per 200 hpf (severe)
Red pulp expansion
Score 0	No expansion
Score 1+	Minimal expansion
Score 2+	Mild expansion
Score 3+	Moderate expansion
Score 4+	Severe expansion