Changes in liver architecture |
Ballooning degeneration |
|
Score 0 |
No ballooning degeneration |
Score 1+ |
Minimal enlargement in few hepatocytes |
Score 2+ |
Mild enlargement in many hepatocytes |
Score 3+ |
Moderate enlargement in most hepatocytes |
Score 4+ |
Severe enlargement in most hepatocytes |
|
Inflammation |
Score 0 |
No inflammatory foci |
Score 1+ |
1 inflammatory foci per 200 hpf |
Score 2+ |
2–4 inflammatory foci per 200 hpf |
Score 3+ |
>4 inflammatory foci per 200 hpf |
|
Apoptotic cells |
Score 0 |
No apoptotic cells |
Score 1+ |
Few apoptotic cells |
|
Fibrosis |
Score 0 |
No fibrosis |
Score 1+ |
Portal/sinusoidal minimal fibrosis |
Score 2+ |
Portal/sinusoidal mild fibrosis |
Score 3+ |
Bridging fibrosis |
Score 4+ |
Cirrhosis |
|
Changes in spleen architecture |
Lymphoid necrosis |
Score 0 |
No necrotic foci |
Score 1+ |
<5% necrotic foci per 200 hpf (mini) |
Score 2+ |
5–25 necrotic foci per 200 hpf (mild) |
Score 3+ |
25–50 necrotic foci per 200 hpf (moderate) |
Score 4+ |
>50% necrotic foci per 200 hpf (severe) |
|
Red pulp expansion |
Score 0 |
No expansion |
Score 1+ |
Minimal expansion |
Score 2+ |
Mild expansion |
Score 3+ |
Moderate expansion |
Score 4+ |
Severe expansion |