Fig. 5.

Effect of autophagy inhibition by HCQ on tumors in vivo. Six NSG mice of each group received a s.c injection of 5x10⁶ IGR-N91 cells. When tumors reached 100 mm³, mice were administered vincristine (0.4 mg/kg/day), HCQ (60 mg/kg), an association of vincristine and HCQ or vehicle (saline) for 9 days. The tumor size of the four groups of mice was compared during this period