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. 2016 Nov 14;16:890. doi: 10.1186/s12885-016-2897-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Patient selection and exclusion criteria. Patients were stratified into 3 groups by their serum tumor markers: double positive (Double +): CA 19-9⁺/CYFRA 21-1⁺; single positive (Single +): either CA 19-9⁺ or CYFRA 21-1⁺; and double negative (Double −): CA 19-9⁻/CYFRA 21-1⁻. Median survival time of each group is indicated in months (with ranges). ALAD: advanced lung adenocarcinoma; CYFRA 21-1: cytokeratin 19 fragments; CA 19-9: carbohydrate antigen 19-9; + positive; −: negative; MST: median survival time